Search results for "B cell epitope"

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PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses

2021

Contains fulltext : 232076.pdf (Publisher’s version ) (Open Access) Tumor-specific neoantigens can be highly immunogenic, but their identification for each patient and the production of personalized cancer vaccines can be time-consuming and prohibitively expensive. In contrast, tumor-associated antigens are widely expressed and suitable as an off the shelf immunotherapy. Here, we developed a PLGA-based nanoparticle vaccine that contains both the immunogenic cancer germline antigen NY-ESO-1 and an α-GalCer analog IMM60, as a novel iNKT cell agonist and dendritic cell transactivator. Three peptide sequences (85-111, 117-143, and 157-165) derived from immunodominant regions of NY-ESO-1 were se…

CD4-Positive T-Lymphocyteslcsh:Immunologic diseases. AllergyCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]T cellmedicine.medical_treatment[SDV]Life Sciences [q-bio]ImmunologyCD8-Positive T-Lymphocyteschemistry.chemical_compoundPolylactic Acid-Polyglycolic Acid CopolymerAntigenmedicinepeptide vaccineHumansImmunology and AllergyCytotoxic T cellNY-ESO-1B cellOriginal ResearchB-LymphocytesDrug CarriersDendritic cellImmunotherapyCD4 T cellPLGA nanoparticleIMM60Peptide FragmentsNeoplasm Proteins[SDV] Life Sciences [q-bio]PLGAmedicine.anatomical_structurechemistryCD8 T cellCancer researchB cell epitopeiNKT cellNanoparticleslcsh:RC581-607CD8
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The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of m…

1998

SUMMARY In a previous study it was shown that La/SSB contains four linear epitopes, p147–154, p291–302, p301–318 and p349–364. The aim of the present study was to investigate the value of the synthetic epitope analogues of the La/SSB autoantigen for the detection of antibodies to La/SSB, in comparison with recombinant La and fragments of this protein. A total of 122 sera with anti-La/SSB activity, from patients with primary Sjögren's syndrome (pSS) or systemic lupus erythematosus (SLE), were tested in various peptide-based assays. In addition, 62 sera from pSS or SLE patients with other autoantibody specificities and 95 sera from healthy individuals were used as controls. The autoantibody s…

systemic lupusantigenic peptidesMolecular Sequence DataImmunologyDot blotPeptideprimary sjogrens-syndromeBiologyAutoantigensSensitivity and SpecificityEpitopelaw.inventionsjogren's syndromeEpitopesAntigenlawmedicineantibodiesHumansImmunology and AllergyAmino Acid SequenceAutoantibodiesImmunoassaychemistry.chemical_classificationla/ssbcriteriaLinear epitopemedicine.diagnostic_testla ss-bAutoantibodyOriginal Articlessystemic lupus-erythematosusautoantigenRecombinant ProteinsSjogren's SyndromeclassificationRibonucleoproteinschemistryImmunoassayImmunologyRecombinant DNAdiagnostic valueb cell epitopesClinical and Experimental Immunology
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